Pregabalin may interact with other medications


Pregabalin oral capsules can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance alters the way a drug works. This can be harmful or prevent the drug from working properly.


To help avoid interactions, your doctor should carefully manage all of your medications. Be sure to tell your doctor about any medications, vitamins or herbs you are taking. To learn how this drug interacts with other medications you are taking, consult your doctor or pharmacist.


Examples of drugs that may cause interactions with pregabalin are listed below.


An interaction that causes an increase in side effects

Taking pregabalin and certain medications can cause more side effects. These drugs include:

Diabetes drugs such as rosiglitazone and pioglitazone. Taking these drugs with pregabalin can cause weight gain or swelling of the hands and feet. If you have heart problems, taking these drugs together can increase your risk of developing heart failure.


Opioid painkillers like oxycodone. Taking these drugs with pregabalin can cause dizziness, drowsiness and breathing problems. In some cases, it can lead to death.


A sedative (a drug that makes you drowsy) or an anti-anxiety medication such as lorazepam. Taking these drugs with pregabalin can cause dizziness, drowsiness and breathing problems. In some cases, it can lead to death.


Blood pressure medications such as captopril, enalapril or lisinopril. Taking these drugs with pregabalin can cause swelling and hives.


Disclaimer: Our goal is to provide you with the most relevant and up-to-date information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always discuss with your healthcare provider possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter medications that you are taking.


For men planning to have children: Animal studies have shown that the drug causes changes in sperm and makes male animals less fertile. In addition, birth defects have been found in babies of male animals treated with the drug. It is not clear whether these problems would occur in people taking the drug.

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